Mechanisms of resistance to cisplatin
WebThe first is the reduction in the accumulation of the drug intracellular. 17 Reduced accumulation of drug is a significant mechanism that results into resistance and reductions in accumulation of drugs by a factor of between 20% to70% could cause resistance of cisplatin by a factor of 3 to 40 fold respectively. 18 However as Koberle et al ... WebThe intracellular targets and mechanisms of action/resistance of oxaliplatin differ from that of its predecessors, cisplatin and carboplatin. It is important to note that oxaliplatin is more active in colon cells [ 6 ], and that cisplatin-resistant cell lines are sensitive to oxaliplatin [ 7, 8 ]. Intracellular targets and mechanisms of action
Mechanisms of resistance to cisplatin
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WebJan 20, 2024 · Therefore, revealing the underlying mechanisms of chemotherapy resistance in LSCC and identifying novel biomarkers for targeted therapy are urgently required to improving the dismal outcome of this disease. ... Upregulation of FOXD2-AS1 enhanced cisplatin resistance of laryngeal cancer cells in vitro. WebJul 1, 2001 · Mechanisms of resistance to cisplatin. The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules.
WebFeb 27, 2013 · Decreased cellular uptake of cisplatin by resistant cells is one of the major mechanisms of resistance described in vitro. The mechanism responsible for reduced cisplatin accumulation in resistant cells may be ascribed to either an inhibition in drug uptake, an increase in drug efflux, or both. WebOct 22, 2024 · 2.2 Epigenetic Mechanisms and Cisplatin Resistance in OSCC The epigenetic modifications include several different forms such as methylation, histone modification, and regulation of non-coding RNAs. Genetic mechanisms and epigenetic mechanisms influence each other and work together to obtain the characteristics of cancer ( 26 ).
WebApplications of Machine Learning to Predict Cisplatin Resistance in Lung Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Gao Y, Lyu Q, Luo P , Li M, Zhou R, Zhang J , Lyu Q. Received 21 July 2024. Accepted for publication 3 September 2024 WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that cisplatin can be inactivated by this protein with the aid of 2 …
WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased …
WebJul 28, 2024 · Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical … songs that mention decemberWebOct 22, 2024 · The mechanisms of cisplatin resistance based on transport process in OSCC are reviewed below . FIGURE 4. Figure 4 A model of transport process-mediated cisplatin … small game project ideasWebMar 28, 2024 · Objective: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione. small game python codeWebApr 12, 2024 · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative … small game program in c++WebAug 1, 2001 · One established mechanism for cisplatin resistance is evasion of cell apoptosis following long-term use of cisplatin (10), which results in resistance to … small game python codingsongs that mention montanaWebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of … songs that mention morgan wallen